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All of Bio-Link.org
Links to Sites of Interest to Biotechnologists

National Science Foundation
Advanced Technological Education Centers

- The NSF ATE Center for Biotechnology
- Advanced Technological Education Links to Project Web Sites

Biotechnology Industry
This is the listing of the member companies of the Biotechnology Industry Organization (BIO), the international organization of the biotechnology industry.

The National Biotech Register
An up-to-date reference guide on research and product development activity in the Biotech Industry. Outlines the focus of 2200 leading companies indexed by research activity and classified. Used as a tool to network and exchange ideas and discoveries. May also be used to facilitate marketing plans for site selection, career advancement, product search, and finding supplies.



Industry Skill Standards

Biosceince Industry Skill Standards
This document contains the Bioscience Industry Skill Standards. It was prepared by the Educational Development Center, Inc. in Newton, MA.

Agricultural Biotechnology Skill Standards
This document contains the Agricultural Biotechnology Skill Standards. It was prepared by the Future Farmers of America.

Combined Academic Knowledge Techncial Skills, and Employability Skills from Bioscience and Agricultural Biotechnology Skills Standards.
This document was prepared by Dr. Judith Leff from Education Development Center, Inc. and Dr. Jeff Moss from FFA Foundation, Inc. The Skills Standards were developed with the assistance of biotechnology educators and industry representatives.



Biotechnology Books & Reviews

Biotechnology books reviewed by Biotechnology faculty with links to online book vendors. If you would like to review a book email the review to: nwarren@madison.tec.wi.us.

Biotechnology Super Sites

Access Excellence Web Site
Dedicated to biotechnology for teachers, faculty and students of modern biology.

"Pioneering Biotechnology Curriculum"
California Community Colleges through the EDNet Initiative have participated in sharing curriculum and instructional materials and have them online

Harvard University Bio pages
A comprehensive list of and links to resources for modern biology, including links to journals.

The National Center for Biotechnology Information
Very minimal but very impressive.

Molecular Biology (Biotechnology Research and Development)
34 short, easy to understand and beautifully illustrated articles to educate physicians in biotechnological methods produced between July 1994 and September 1996 by the New England Journal of Medicine.

"Experimental Study Group" - Online Textbook
An online textbook of modern biology produced the "Experimental Study Group" at MIT. A review of basic chemistry and an in depth discussion of large molecules, Central Dogma, the Lac operon and other regulated systems in procaryotes, Southern, Western and Northern blots, PCR.

Biotechnology Diagrams
A series of labeled diagrams with explanations representing the important processes of biotechnology produced from Access Excellence at Genentech. Each diagram is followed by a summary of information, providing a context for the process illustrated.

BIOSIS
BIOSIS, established in 1926, is a not-for-profit organization whose mission is to foster the growth, communication and use of biological knowledge for the common good. By accumulating the world's largest collection of abstracts and bibliographic references to worldwide biological and medical literature and organizing this information for easy access, BIOSIS provides vital sources of information for life scientists.

Federal Bio-Technology Transfer Directory
A new Internet Web database that currently abstracts and indexes about 1,500 federal patents; 1,000 patent applications; 1,400 patent licenses (450 exclusive); and 950 CRADAs in the biomedical and related biotechnology areas.

Virtual Library: Biotechnology
This directory covers biotechnology, pharmaceutical development, genetic engineering, medical device development, and related fields such as pharmacology and toxicology. It differs from Biosciences in that Biotechnology places more emphasis on product development and the delivery of products and services. This field will also include some helpful medical informatics and health care delivery references.

Bacteriophage
This site shows infection of a bacterium by a bacteriophage. It shows the injection of DNA into the bacteria by the bacteriophage, the multiplication of bacteriophages within the bacterium and lysis of the bacterium.



Biotechnology Instructional Materials Web Sites

Check out this list of on-line resources for the Biotechnology educator. Both general interest and specific Biotechnology links are included.



Cytogenetics

Genome Machine
The experimental, graphical user interface to the Genome DataBase at Johns Hopkins University. You can perform such queries of the GDB as, "What genes have been mapped to a particular chromosome location (i.e. cytogenetic band)?".

Chromosome Regions to Genes
This is a great site linking specific human chromosome regions to genes that cause a disease.



Ethics in Biotechnology

The Edmonds Institute
A non-profit, public interest organization dedicated to education about environment, technology, and intellectual property rights. It has a manual on how to test the effect of genetically engineered organisms on humans, and a really good historical look at the ethics/public opinion of biotech.



Genomics, Proteomics, and Bioinformatics

Darwin 2000 The Bioactive Site
A Web Site for Student Research in Bioinformatics, Molecular Biology, and Evolution, this is a site developed specifically for college level courses. It contains a series of modules, each focusing on the use of a specific biocomputing tool. Scroll down to the middle of the page to find a series of four interactive exercises. The interactive exercises contained within each module explain how to use the tool, what kinds of scientific questions can be investigated using the tool, and what concepts in molecular biology, biochemistry, and evolution are illustrated through these investigations.
Compiled by Dr. Rick Hershberger Carlow College

National Center for Biotechnology Information: Education Page
This website has more information on the field of bioinformatics, including information about additional applications of bioinformatics in biology. It also features a more extensive tutorial for those who wish to learn more about BLAST.

National Center for Biotechnology Information: Sequence Similarity Searching
BLAST is an example of a program that carries out sequence similarity searching. This site explains sequence similarity searching in more detail, defining words like homology and paralogy.

current Good Manufacturing Practices (cGMP)

Covance - cGMP and ICH-compliant Stability Chambers
Covance provides comprehensive cGMP and ICH-compliant stability programs and has both walk-in and reach-in stability chambers that are continuously monitored. Chamber conditions are all ICH-qualified and specialty conditions can be provided to meet customer-specific requirements.

Government Regulations for the Manufacture of Human Pharmaceuticals
(including the Biopharmaceuticals: Proteins and Peptides)
Title 21--Food and Drugs, CHAPTER I--FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES, PART 211--CURRENT GOOD MANUFACTURING PRACTICE FOR FINISHED PHARMACEUTICALS.

Human Drug cGMP Notes
Current Good Manufacturing Practice Issues on Human Use Pharmaceuticals.

21 Code of Federal Regulations, Part 11
This document relates to the use of electronic records and signatures in manufacturing human pharmaceuticals.

Upstream Processing (Cell Culture)

Recombinant Cells -- Making Protein
The premier source for recombinant cells for making proteins in suspension culture.

Bacteria Grow & Multiply
This site shows animated gifs of various cellular processes and this example is entitled, "Bacteria Grow and Multiply". It shows images of bacteria as they multiply and then shows an animated gif of a growth curve charting the different stages (lag, log, stationary and death phases) of the growth curve over time.



Downstream Processing (Protein Purification)

Purification & Crystallization
This is a PowerPoint presentation on Purification and Crystallization of lectin from blue bells for the purpose of x-ray crystallography. It is a simple and effective presentation.

Protein Purification
A New Scientist article on Protein Purification.

"Strategies for Protein Purification and Characterization
A Laboratory Course Manual" from folks at Cold Spring Harbor Laboratories. This web page gives the contents of the book and contains information on ordering the book.

Protein Purification Protocols
A review of "Protein Purification Protocols" by Shawn Doonan, ed., in Methods in Molecular Biology 59. Humana Press, Totowa, NJ. 1996, 405 pp., $64.50.

"The Strategy of Protein Purification
A Virtual Laboratory Class" from the School of Biochemistry and Molecular Biology from the University of Leeds in England. This one looks interesting, but has not been reviewed yet.



Biotechnology Proteins

Protein Course
This is a complete course on proteins from Birkbeck College in England. It is very good and very high end, and easy to comprehend.

Enzyme Proteins
Support for course on enzyme proteins, including theoretical and practical information on protein purification. Mathematically advanced curriculum.

Three-dimensional images of proteins

Biological Therapies
Using the Immune System To Treat Cancer. This site contains brief descriptions of various growth factors (cytokines) involved in defeating the unleashed multiplication of cancer cells.

Harvesting sunshine
A key component of Light Harvesting bacteria has been identified which shows the subtle and elegant way biological systems can use sunshine to create energy. This article discusses how a team of scientists from Scotland have determined the atomic structure of a protein that harvests solar energy in purple bacteria. The harvested light is turned into electrical activity, which is turned into chemical energy.



List Serves/Discussion Groups

bio-link@egroups.com
This is a discussion group for anyone interested in biotechnology, including university and college faculty, high school teachers, students from kindegarten to graduate school, and people in industry.

biz-biotech@netcom.com
This group is reformulating their mission.

bioremediation@bio.gza.com
Did you know that 85% of current environmental remediation utilizes environmental biotechnology methodology? This is a list serve for people interested in environmental biotechnology.

phbiotech@net.bio.net



Organizations

The World Wide Club for the Biological and Medical Community

Scientist Lifeboat

The Career Discussion Forum at Bio Online
One of the most active online discussion forums covering the world of science careers, biotechnology, and pharmaceuticals. This forum has hundreds of archived and current posts related to topics about careers: various bench science and non-bench science positions, alternative careers, and job search related discussion. You will find it of interest whether you are just starting out or whether you are advancing on a senior-level career track.

The BioChemNet
A gateway to the best chemistry and molecular biology educational resources on the Web. It now features a weekly updated "News & Reviews" section.

Biology resources
Directory of Biology related websites from Science-Lab.com

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